Torsin family 1, member A (torsin A)
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Torsin-1A
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P637
  value: NP_659133
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: unfolded protein binding
additional property: PropertyValue
  property ID: P680
  value: misfolded protein binding
additional property: PropertyValue
  property ID: P681
  value: cell projection
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum lumen
additional property: PropertyValue
  property ID: P681
  value: nuclear envelope
additional property: PropertyValue
  property ID: P682
  value: regulation of dopamine uptake involved in synaptic transmission
additional property: PropertyValue
  property ID: P682
  value: regulation of protein localization to cell surface
additional property: PropertyValue
  property ID: P682
  value: nuclear envelope organization
additional property: PropertyValue
  property ID: P702
  value: Tor1a
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000028200
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9ER39
    source count: 1
    confidence: 0.2
  P361:
    value: Q24783894
    source count: 1
    confidence: 0.2
    value label: Torsin-1A
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P637:
    value: NP_659133
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14633875
    source count: 1
    confidence: 0.2
    value label: unfolded protein binding
  P680:
    value: Q14862712
    source count: 1
    confidence: 0.2
    value label: misfolded protein binding
  P680:
    value: Q14864842
    source count: 4
    confidence: 0.8
    value label: cytoskeletal protein binding
  P680:
    value: Q14860372
    source count: 3
    confidence: 0.6
    value label: ATPase activity
  P681:
    value: Q14353100
    source count: 1
    confidence: 0.2
    value label: cell projection
  P681:
    value: Q14633848
    source count: 5
    confidence: 1.0
    value label: endoplasmic reticulum lumen
  P681:
    value: Q14865821
    source count: 2
    confidence: 0.4
    value label: nuclear envelope
  P681:
    value: Q14349455
    source count: 3
    confidence: 0.6
    value label: membrane
  P681:
    value: Q671136
    source count: 4
    confidence: 0.8
    value label: synaptic vesicle
  P682:
    value: Q14916284
    source count: 3
    confidence: 0.6
    value label: regulation of dopamine uptake involved in synaptic transmission
  P682:
    value: Q14864693
    source count: 3
    confidence: 0.6
    value label: regulation of protein localization to cell surface
  P682:
    value: Q14911832
    source count: 2
    confidence: 0.4
    value label: nuclear envelope organization
  P682:
    value: Q21109270
    source count: 1
    confidence: 0.2
    value label: ER-associated misfolded protein catabolic process
  P682:
    value: Q15313788
    source count: 1
    confidence: 0.2
    value label: organelle organization
  P702:
    value: Q18256771
    source count: 1
    confidence: 0.2
    value label: Tor1a
  P703:
    value: Q83310
    source count: 1
    confidence: 0.2
    value label: house mouse
  P705:
    value: ENSMUSP00000028200
    source count: 1
    confidence: 0.2
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-05-09
citations:
  source: SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA
  stated in qid: Q28506171
  retrieved: 2019-05-09
citations:
  source: TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton
  stated in qid: Q24317502
  retrieved: 2019-05-09

source: The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein
stated in qid: Q24678547
retrieved: 2019-05-09

source: A molecular mechanism underlying the neural-specific defect in torsinA mutant mice
stated in qid: Q28594816
retrieved: 2019-05-09

source: Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis
stated in qid: Q24338612
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA
stated in qid: Q22001542
retrieved: 2019-02-14

source: Immunocytochemical characterization of torsin proteins in mouse brain
stated in qid: Q28511582
retrieved: 2019-05-09

source: Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope
stated in qid: Q28589351
retrieved: 2019-05-09

source: UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination
stated in qid: Q28594993
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21991859
domain: protein
level: standard
html url: https://4ort.xyz/entity/torsin-family-1-member-a-torsin-a-
markdown url: https://4ort.xyz/entity/torsin-family-1-member-a-torsin-a-.md
facts url summary: https://4ort.xyz/entity/torsin-family-1-member-a-torsin-a-/facts.json
facts url standard: https://4ort.xyz/entity/torsin-family-1-member-a-torsin-a-/facts.json
facts url full: https://4ort.xyz/entity/torsin-family-1-member-a-torsin-a-/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-10T19:15:24.004076Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:59.184953+00:00Z