Toll/interleukin-1 receptor homology (TIR) domain superfamily
cysteine-rich flanking region, C-terminal
transmembrane signaling receptor activity
positive regulation of MHC class II biosynthetic process
cellular response to mechanical stimulus
Toll/interleukin-1 receptor homology (TIR) domain, protein family
Cysteine-rich flanking region, C-terminal domain, protein family
Toll/interleukin-1 receptor homology (TIR) domain
lipopolysaccharide immune receptor activity
positive regulation of interleukin-8 production
positive regulation of ERK1 and ERK2 cascade
CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex
WDFY 1 mediates TLR 3/4 signaling by recruiting TRIF
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4
Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis
Toll-like receptor 4-mediated activation of murine mast cells