Toll-like receptor 4
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: paclitaxel
additional property: PropertyValue
  property ID: P361
  value: Toll/interleukin-1 receptor homology (TIR) domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Leucine-rich repeat domain superfamily
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: Leucine-rich repeat
additional property: PropertyValue
  property ID: P527
  value: cysteine-rich flanking region, C-terminal
additional property: PropertyValue
  property ID: P527
  value: leucine-rich repeat, typical subtype
additional property: PropertyValue
  property ID: P637
  value: NP_067272
additional property: PropertyValue
  property ID: P637
  value: XP_036019857
additional property: PropertyValue
  property ID: P638
  value: 2Z64
additional property: PropertyValue
  property ID: P638
  value: 3VQ1
additional property: PropertyValue
  property ID: P638
  value: 3VQ2
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: transmembrane signaling receptor activity
additional property: PropertyValue
  property ID: P680
  value: lipopolysaccharide binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: perinuclear region of cytoplasm
additional property: PropertyValue
  property ID: P682
  value: positive regulation of MHC class II biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: positive regulation of JNK cascade
additional property: PropertyValue
  property ID: P682
  value: cellular response to mechanical stimulus
additional property: PropertyValue
  property ID: P702
  value: Tlr4
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000102988
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000045770
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:Q9QUK6
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/Q9QUK6
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/Q9QUK6
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 49
      unique citations norm: 0.019
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 49
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q423762
    source count: 1
    confidence: 0.2
    value label: paclitaxel
  P352:
    value: Q9QUK6
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797047
    source count: 1
    confidence: 0.2
    value label: Toll/interleukin-1 receptor homology (TIR) domain superfamily
  P361:
    value: Q24781235
    source count: 1
    confidence: 0.2
    value label: Leucine-rich repeat domain superfamily
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83147204
    source count: 1
    confidence: 0.2
    value label: Toll/interleukin-1 receptor homology (TIR) domain, protein family
  P361:
    value: Q83163261
    source count: 1
    confidence: 0.2
    value label: Cysteine-rich flanking region, C-terminal domain, protein family
  P527:
    value: Q24739837
    source count: 1
    confidence: 0.2
    value label: Leucine-rich repeat
  P527:
    value: Q24782645
    source count: 1
    confidence: 0.2
    value label: cysteine-rich flanking region, C-terminal
  P527:
    value: Q24783125
    source count: 1
    confidence: 0.2
    value label: leucine-rich repeat, typical subtype
  P527:
    value: Q24780090
    source count: 1
    confidence: 0.2
    value label: Toll/interleukin-1 receptor homology (TIR) domain
  P637:
    value: NP_067272
    source count: 1
    confidence: 0.2
  P637:
    value: XP_036019857
    source count: 1
    confidence: 0.2
  P638:
    value: 2Z64
    source count: 1
    confidence: 0.2
  P638:
    value: 3VQ1
    source count: 1
    confidence: 0.2
  P638:
    value: 3VQ2
    source count: 1
    confidence: 0.2
  P638:
    value: 5IJB
    source count: 1
    confidence: 0.2
  P638:
    value: 5IJD
    source count: 1
    confidence: 0.2
  P680:
    value: Q167149
    source count: 12
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14864356
    source count: 2
    confidence: 0.4
    value label: transmembrane signaling receptor activity

value: Q14864979
source count: 4
confidence: 0.8
value label: lipopolysaccharide binding

value: Q14907423
source count: 4
confidence: 0.8
value label: lipopolysaccharide immune receptor activity

value: Q14819233
source count: 2
confidence: 0.4
value label: signaling receptor binding

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14330632
source count: 2
confidence: 0.4
value label: perinuclear region of cytoplasm

value: Q189094
source count: 2
confidence: 0.4
value label: cell surface

value: Q14327652
source count: 1
confidence: 0.2
value label: integral component of membrane

value: Q14864458
source count: 2
confidence: 0.4
value label: positive regulation of MHC class II biosynthetic process

value: Q14864950
source count: 4
confidence: 0.8
value label: positive regulation of JNK cascade

value: Q14859645
source count: 2
confidence: 0.4
value label: cellular response to mechanical stimulus

value: Q14860511
source count: 3
confidence: 0.6
value label: positive regulation of interleukin-8 production

value: Q14821388
source count: 2
confidence: 0.4
value label: positive regulation of ERK1 and ERK2 cascade

value: Q14914099
source count: 1
confidence: 0.2
value label: Tlr4

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000102988
source count: 1
confidence: 0.2

value: ENSMUSP00000045770
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:Q9QUK6
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/Q9QUK6
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/Q9QUK6
source count: 1
confidence: 0.2

source: CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex
stated in qid: Q28509313
retrieved: 2019-05-09

source: WDFY 1 mediates TLR 3/4 signaling by recruiting TRIF
stated in qid: Q24321402
retrieved: 2019-05-09

source: The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
stated in qid: Q28115270
retrieved: 2019-05-09

source: The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
stated in qid: Q28507440
retrieved: 2019-05-09

source: Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.
stated in qid: Q34208916
retrieved: 2019-05-09

source: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
stated in qid: Q24292781
retrieved: 2019-05-09

source: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
stated in qid: Q30577895
retrieved: 2019-05-09

source: An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1
stated in qid: Q27671851
retrieved: 2019-05-09

source: Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
stated in qid: Q27678726
retrieved: 2019-05-09

source: Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology
stated in qid: Q63345230
retrieved: 2019-05-09

source: Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
stated in qid: Q36843563
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-16

source: Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization
stated in qid: Q39016000
retrieved: 2019-05-09

source: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
stated in qid: Q28511151
retrieved: 2019-05-09

source: TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
stated in qid: Q28504462
retrieved: 2019-05-09

source: The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
stated in qid: Q28512240
retrieved: 2019-05-09

source: Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome
stated in qid: Q24306498
retrieved: 2019-05-09

source: Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
stated in qid: Q24303416
retrieved: 2019-05-09

source: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
stated in qid: Q28506984
retrieved: 2019-05-09

source: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4
stated in qid: Q28513447
retrieved: 2019-05-09

source: Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages
stated in qid: Q28508577
retrieved: 2019-05-09

source: The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
stated in qid: Q28504661
retrieved: 2019-05-09

source: Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1
stated in qid: Q28511836
retrieved: 2019-05-09

source: Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
stated in qid: Q28588629
retrieved: 2019-05-09

source: Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
stated in qid: Q28509616
retrieved: 2019-05-09

source: TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
stated in qid: Q28513789
retrieved: 2019-05-09

source: Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis
stated in qid: Q28591514
retrieved: 2019-05-09

source: Toll-like receptor 4-mediated activation of murine mast cells
stated in qid: Q28585932
retrieved: 2019-05-09

wikidata id: Q14914104
domain: protein
level: standard
html url: https://4ort.xyz/entity/toll-like-receptor-4
markdown url: https://4ort.xyz/entity/toll-like-receptor-4.md
facts url summary: https://4ort.xyz/entity/toll-like-receptor-4/facts.json
facts url standard: https://4ort.xyz/entity/toll-like-receptor-4/facts.json
facts url full: https://4ort.xyz/entity/toll-like-receptor-4/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T15:28:25.493591Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:46:20.697850+00:00Z