# Toll-like receptor 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q14914104](https://www.wikidata.org/wiki/Q14914104)  
**Source**: https://4ort.xyz/entity/toll-like-receptor-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9QUK6)
4. Q20641742
5. [CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
6. [WDFY 1 mediates TLR 3/4 signaling by recruiting TRIF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
7. [The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
8. [The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
9. [Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
10. [Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
11. [The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
12. [An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
13. [Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
14. [Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
15. [Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUK6&geneProductId=UniProtKB:Q9QUK6)
19. [Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
20. [Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
21. [TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
22. [The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
23. [Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
24. [Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
25. [CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
26. [Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
27. [Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
28. [The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
29. [Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
30. [Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
31. [Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
32. [TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
33. [Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
34. [Toll-like receptor 4-mediated activation of murine mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
35. [MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
36. [Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
37. [The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
38. [Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
39. [A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
40. [The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
41. [LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
42. [Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
43. [Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
44. [TLR4 mutations are associated with endotoxin hyporesponsiveness in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
45. [CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
46. [Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
47. [Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6)
48. ensembl Release 106
49. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)