# Toll-like receptor 4

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561771](https://www.wikidata.org/wiki/Q28561771)  
**Source**: https://4ort.xyz/entity/toll-like-receptor-4-q28561771


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9QX05)
3. Q20641742
4. [Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
7. [Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
8. [Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
9. [Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
10. [Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
11. [Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
12. [Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
13. [Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
14. [Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
15. [Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
16. [Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
17. [Toll-like receptor 4 expression and cytokine secretion in microglial cells induced by IgG stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
18. [Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
19. [Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-kappaB expression in rat mammary tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
20. [Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
21. [Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
22. [Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
23. [Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
24. [Gangliosides trigger inflammatory responses via TLR4 in brain glia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
25. [Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
26. [Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
27. [Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
28. [Tibia tumor-induced cancer pain involves spinal p38 mitogen-activated protein kinase activation via TLR4-dependent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
29. [Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
30. [Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-κB pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
31. [Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
32. [Effects of Gold Nanoparticles on Endotoxin-Induced Uveitis in Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX05)
33. ensembl Release 106