# TNF receptor superfamily member 1A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110955](https://www.wikidata.org/wiki/Q21110955)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Tumor_necrosis_factor_receptor_1)  
**Source**: https://4ort.xyz/entity/tnf-receptor-superfamily-member-1a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19438)
3. Q20641742
4. [A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
5. [Effect of antibodies to rat and human cerebral cortex and white matter on heterologous T- and B-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
6. [Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
7. [A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
8. [SH3RF2 functions as an oncogene by mediating PAK4 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
9. [RAIDD is a new 'death' adaptor molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
10. [MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
11. [Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
12. [Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
13. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
14. [IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
15. [Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
16. [The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
17. [The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
18. [Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
19. [Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
20. [Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
21. [Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
22. [The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
23. [Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
24. [TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
25. [Riboflavin kinase couples TNF receptor 1 to NADPH oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
26. [Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
27. [The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
28. [The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
29. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
30. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
31. [Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
32. [Molecular cloning and expression of a receptor for human tumor necrosis factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
34. [TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
35. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
36. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
37. [The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
38. [Molecular cloning and expression of a receptor for human tumor necrosis factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
41. [The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
42. [TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
43. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
44. [Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
45. [Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
46. [The shedding activity of ADAM17 is sequestered in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19438&geneProductId=UniProtKB:P19438)
47. [Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
48. [Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
49. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)
50. [The shedding activity of ADAM17 is sequestered in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19438)