# TNF receptor associated factor 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4050614](https://www.wikidata.org/wiki/Q4050614)  
**Source**: https://4ort.xyz/entity/tnf-receptor-associated-factor-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y4K3)
3. Q20641742
4. [Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
5. [Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
7. [The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
8. [NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
9. [Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
10. [WDFY 1 mediates TLR 3/4 signaling by recruiting TRIF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
11. [The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
12. [RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
13. [The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
14. [IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
15. [A Novel Zinc Finger Protein That Inhibits Osteoclastogenesis and the Function of Tumor Necrosis Factor Receptor-associated Factor 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
16. [Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
17. [The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
18. [TRAF family proteins link PKR with NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
19. [Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
20. [TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
21. [NUMBL interacts with TRAF6 and promotes the degradation of TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
22. [A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
23. [IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
24. [Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
25. [Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
26. [Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
27. [INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
28. [Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
29. [The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
30. [mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
31. [WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
32. [Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
33. [Distinct molecular mechanism for initiating TRAF6 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
34. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
35. [Systematic Analysis of Dimeric E3-RING Interactions Reveals Increased Combinatorial Complexity in Human Ubiquitination Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
36. [The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
37. [Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
38. [IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
39. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
40. [Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
41. [An organelle-specific protein landscape identifies novel diseases and molecular mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
42. [ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
43. [The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
44. [Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
45. [NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
46. [T6BP, a TRAF6-interacting protein involved in IL-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
47. [Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
48. [Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
49. [Isolation and characterization of two novel A20-like proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)
50. [Protein Kinase C-δ Negatively Regulates T Cell Receptor-induced NF-κB Activation by Inhibiting the Assembly of CARMA1 Signalosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K3)