# TNF receptor-associated factor 6

> mammalian protein found in Mus musculus

**Wikidata**: [Q21497539](https://www.wikidata.org/wiki/Q21497539)  
**Source**: https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q21497539


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70196)
3. Q20641742
4. [Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
5. [TRAF6‐mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
7. [TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
9. [TRAF6‐mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
10. [FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
11. [The LIM Protein, LIMD1, Regulates AP-1 Activation through an Interaction with TRAF6 to Influence Osteoclast Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
12. [Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
13. [Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
14. [The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
15. [Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
16. [Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
17. [Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
18. [The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
19. [TLR signalling augments macrophage bactericidal activity through mitochondrial ROS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
20. [Hsp70 inhibits lipopolysaccharide‐induced NF‐κB activation by interacting with TRAF6 and inhibiting its ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
21. [ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
22. [FLN29, a Novel Interferon- and LPS-inducible Gene Acting as a Negative Regulator of Toll-like Receptor Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
23. [Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
24. [IRAK‐M mediates Toll‐like receptor/IL‐1R‐induced NFκB activation and cytokine production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
25. [NF‐κB activator Act1 associates with IL‐1/Toll pathway adaptor molecule TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
26. [Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
27. [Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
28. [The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
29. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
30. [Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
31. [A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
32. [Inflammatory cardiac valvulitis in TAX1BP1‐deficient mice through selective NF‐κB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
33. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
35. [The IRAK-1-BCL10-MALT1-TRAF6-TAK1 Cascade Mediates Signaling to NF-κB from Toll-like Receptor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
36. [HOIL-1L Interacting Protein (HOIP) as an NF-κB Regulating Component of the CD40 Signaling Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
37. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
38. [TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
39. [Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
40. [TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
41. [Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
42. [Traf6 is essential for murine tooth cusp morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
43. [Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
44. [Human lactoferrin activates NF‐κB through the Toll‐like receptor 4 pathway while it interferes with the lipopolysaccharide‐stimulated TLR4 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
45. [Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
46. [Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
47. [The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196)
48. [Characteristics and Biological Functions of TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
49. [Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)
50. [Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor–interleukin 1 receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196)