# TNF receptor associated factor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7671245](https://www.wikidata.org/wiki/Q7671245)  
**Source**: https://4ort.xyz/entity/tnf-receptor-associated-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12933)
3. Q20641742
4. [Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
6. [Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12933&geneProductId=UniProtKB:Q12933)
7. [De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
8. [TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
9. [RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
10. [Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
11. [TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
12. [Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
13. [Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
14. [PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
15. [Asymmetric recruitment of cIAPs by TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
16. [Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
17. [TRAF family proteins link PKR with NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
18. [FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
19. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
20. [Protein interactions of the transcription factor Hoxa1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
21. [Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
22. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
23. [TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
24. [The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
25. [CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
26. [Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
27. [The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
28. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
29. [T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
30. [MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
31. [A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
32. [Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
33. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
34. [Unconventional ligand activation of herpesvirus entry mediator signals cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
35. [Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
36. [AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
37. [A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
38. [OTUB1 modulates c-IAP1 stability to regulate signalling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
39. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
40. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
41. [A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
42. [Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
43. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
44. [ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
45. [TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
46. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
47. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
48. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
49. [The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)
50. [MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933)