# TNF alpha induced protein 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109230](https://www.wikidata.org/wiki/Q21109230)  
**Source**: https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21580)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
5. [De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
6. [T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
7. [A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
8. [A20, an inhibitor of cell death, self-associates by its zinc finger domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
11. [Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
12. [A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
13. [A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
14. [The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
15. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
16. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
18. [ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
19. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
20. [ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
21. [Isolation and characterization of two novel A20-like proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
22. [A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
23. [The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
24. [The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
25. [OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
26. [De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
27. [Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
28. [OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
29. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
30. [Isolation and characterization of two novel A20-like proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21580&geneProductId=UniProtKB:P21580)
31. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
32. [A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
33. [A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
34. [Role of the A20-TRAF6 Axis in Lipopolysaccharide-mediated Osteoclastogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
35. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
36. [A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
37. [A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21580)
38. Ensembl Release 99
39. UMLS 2023