# titin

> largest known protein found in muscles of Homo sapiens

**Wikidata**: [Q74314](https://www.wikidata.org/wiki/Q74314)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Titin)  
**Source**: https://4ort.xyz/entity/titin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8WZ42)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/A2ASS6)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ASS6)
9. [A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
10. [A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
11. [Titin mutations as the molecular basis for dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
12. [Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
13. [Titin mutations as the molecular basis for dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
14. [Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
15. [Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
16. [Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
17. [Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
18. [Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
19. [Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
20. [Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
21. [Structural basis for activation of the titin kinase domain during myofibrillogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
22. [Structural basis for activation of the titin kinase domain during myofibrillogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
23. [Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
24. [α‐Synemin localizes to the M‐band of the sarcomere through interaction with the M10 region of titin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
25. [The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
26. [Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
27. [Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
28. [Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
29. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
30. [A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
31. [Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
32. [Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
33. [Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
34. [The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
35. [Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
36. [The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
37. [The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42)
38. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
39. [A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
40. [The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
41. [Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
42. [Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
43. [Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
44. [Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
45. [The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
46. [Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
47. [Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
48. [α‐Synemin localizes to the M‐band of the sarcomere through interaction with the M10 region of titin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
49. [Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)
50. [The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42)