# TIR domain containing adaptor protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116674](https://www.wikidata.org/wiki/Q21116674)  
**Source**: https://4ort.xyz/entity/tir-domain-containing-adaptor-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P58753)
3. Q20641742
4. [A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
6. [AIP1 Functions as Arf6-GAP to Negatively Regulate TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
7. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
8. [TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
9. [Mal connects TLR2 to PI3Kinase activation and phagocyte polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
10. [The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
11. [Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
12. [Distinct roles of TIR and non‐TIR regions in the subcellular localization and signaling properties of MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
13. [MAPPIT analysis of TLR adaptor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
14. [Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
15. [The Brucella TIR-like protein TcpB interacts with the death domain of MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
16. [Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
17. [Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
18. [Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
19. [Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
20. [Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753)
21. Ensembl Release 99