# Tight junction protein 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21496047](https://www.wikidata.org/wiki/Q21496047)  
**Source**: https://4ort.xyz/entity/tight-junction-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P39447)
3. Q20641742
4. [Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
6. [Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
7. [Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
8. [Bves modulates epithelial integrity through an interaction at the tight junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
9. [Progressive Hearing Loss in Mice Carrying a Mutation inUsp53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
10. [Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
11. [Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
12. [Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin 43 containing gap junctions in cardiac Myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
13. [Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39447&geneProductId=UniProtKB:P39447)
15. [Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
16. [Regulation of connexin43 protein complexes by intracellular acidification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
17. [Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
18. [Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
19. [Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
20. [Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
21. [Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
22. [Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
23. [Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
24. [Nectins localize Willin to cell–cell junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
25. [Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
26. [WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
27. [Multi-PDZ Domain Protein 1 (MUPP1) Is Concentrated at Tight Junctions through Its Possible Interaction with Claudin-1 and Junctional Adhesion Molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
28. [FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
29. [Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
30. [Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
31. [Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
32. [Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
33. [Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
34. [Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
35. [Cdx2 regulates endo-lysosomal function and epithelial cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
36. [Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
37. [Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
38. [Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
39. [Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
40. [The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
41. [E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
42. [Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
43. [Expression and distribution of ZO‐3, a tight junction MAGUK protein, in mouse tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
44. [Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
45. [Distinct subdomain organization and molecular composition of a tight junction with adherens junction features](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
46. [Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
47. [Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
48. [Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
49. [PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)
50. [Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447)