# Three prime repair exonuclease 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981550](https://www.wikidata.org/wiki/Q21981550)  
**Source**: https://4ort.xyz/entity/three-prime-repair-exonuclease-1-q21981550


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q91XB0)
3. Q20641742
4. [Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
5. [The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
7. [Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
8. [Trex1 prevents cell-intrinsic initiation of autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
9. [Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XB0&geneProductId=UniProtKB:Q91XB0)
10. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
11. [Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
12. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XB0&geneProductId=UniProtKB:Q91XB0)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91XB0&geneProductId=UniProtKB:Q91XB0)
14. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
16. [The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
17. [Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
18. [Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
19. [Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
20. [Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
21. [Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
22. [The exonuclease Trex1 restrains macrophage proinflammatory activation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
23. [Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
24. [Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
25. [Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
26. [Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
27. [Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
28. [Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
29. [Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
30. [IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91XB0)
31. ensembl Release 106