# The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

> Research article (PLoS Computational Biology, 2016) · cited 107× · AI/ML

**Wikidata**: [openalex:W2385352626](https://www.wikidata.org/wiki/openalex:W2385352626)  
**Source**: https://4ort.xyz/entity/the-limitations-of-model-based-experimental-design-and-parameter-estimation-in-sloppy-systems