# Telomeric repeat binding factor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109607](https://www.wikidata.org/wiki/Q21109607)  
**Source**: https://4ort.xyz/entity/telomeric-repeat-binding-factor-2-q21109607


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15554)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
5. [Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15554&geneProductId=UniProtKB:Q15554)
6. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15554&geneProductId=UniProtKB:Q15554)
7. [Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15554&geneProductId=UniProtKB:Q15554)
8. [Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
9. [TRF2 Protects Human Telomeres from End-to-End Fusions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
10. [TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
11. [RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
12. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
13. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15554&geneProductId=UniProtKB:Q15554)
14. [Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
15. [Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
16. [The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
17. [ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
18. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
19. [The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
20. [TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
21. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
22. [Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
23. [NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
24. [Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
25. [Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
26. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
27. [A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
28. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
29. [Five dysfunctional telomeres predict onset of senescence in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
30. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
31. [ORC binding to TRF2 stimulates OriP replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
32. [A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
33. [POT1 association with TRF2 regulates telomere length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
34. [Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
35. [A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
36. [Interaction of human Ku70 with TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
37. [RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
38. [XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
39. [TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
40. [TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
41. [PTOP interacts with POT1 and regulates its localization to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
42. [POT1 and TRF2 cooperate to maintain telomeric integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
43. [TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
44. [SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
45. [MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15554&geneProductId=UniProtKB:Q15554)
46. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
47. [Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
48. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
49. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)
50. [MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15554)