# telomeric repeat binding factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130708](https://www.wikidata.org/wiki/Q21130708)  
**Source**: https://4ort.xyz/entity/telomeric-repeat-binding-factor-1-q21130708


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P54274)
3. Q20641742
4. [A human telomeric protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
6. [How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
7. [POT1 as a terminal transducer of TRF1 telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
8. [TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
9. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
10. [TRF1 is a dimer and bends telomeric DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
11. [GNL3L stabilizes the TRF1 complex and promotes mitotic transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
12. [RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
13. [PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
14. [Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
15. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
16. [Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54274&geneProductId=UniProtKB:P54274)
17. [TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54274&geneProductId=UniProtKB:P54274)
18. [Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
19. [Structural basis of selective ubiquitination of TRF1 by SCFFbx4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
20. [Structural Basis of Dimerization-dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
21. [Tankyrase, a poly(ADP-ribose) polymerase at human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
22. [Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal–Hreidarsson syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
23. [Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
24. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
25. [The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
26. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
27. [Tankyrase-1 assembly to large protein complexes blocks its telomeric function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
28. [The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
29. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
30. [Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
31. [NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
32. [A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
33. [The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
34. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
35. [Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
36. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
37. [Protein requirements for sister telomere association in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
38. [A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
39. [TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
40. [Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
41. [RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
42. [TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
43. [The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
44. [PTOP interacts with POT1 and regulates its localization to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
45. [Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
46. [TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
47. [MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
48. [Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54274&geneProductId=UniProtKB:P54274)
49. [The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274)
50. [The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54274&geneProductId=UniProtKB:P54274)