Telomerase reverse transcriptase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O14746
additional property: PropertyValue
  property ID: P361
  value: telomerase
additional property: PropertyValue
  property ID: P361
  value: Telomerase reverse transcriptase
additional property: PropertyValue
  property ID: P361
  value: Telomerase ribonucleoprotein complex - RNA-binding domain, protein family
additional property: PropertyValue
  property ID: P486
  value: C509186
additional property: PropertyValue
  property ID: P527
  value: Telomerase ribonucleoprotein complex - RNA-binding domain
additional property: PropertyValue
  property ID: P527
  value: Reverse transcriptase domain
additional property: PropertyValue
  property ID: P637
  value: NP_001180305
additional property: PropertyValue
  property ID: P637
  value: NP_937983
additional property: PropertyValue
  property ID: P638
  value: 2BCK
additional property: PropertyValue
  property ID: P638
  value: 4B18
additional property: PropertyValue
  property ID: P638
  value: 4MNQ
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: nucleotidyltransferase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: PML body
additional property: PropertyValue
  property ID: P681
  value: nuclear telomere cap complex
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein localization to nucleolus
additional property: PropertyValue
  property ID: P682
  value: telomere maintenance via telomerase
additional property: PropertyValue
  property ID: P682
  value: DNA biosynthetic process
additional property: PropertyValue
  property ID: P702
  value: TERT
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000309572
additional property: PropertyValue
  property ID: P705
  value: ENSP00000334346
additional property: PropertyValue
  property ID: P705
  value: ENSP00000425003
additional property: PropertyValue
  property ID: P2892
  value: C0754515
confidence:
  popularity graph score:
    score: 0.011
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 77
      unique citations norm: 0.03
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 77
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O14746
    source count: 1
    confidence: 0.2
  P361:
    value: Q331839
    source count: 0
    confidence: 0.0
    value label: telomerase
  P361:
    value: Q24720565
    source count: 1
    confidence: 0.2
    value label: Telomerase reverse transcriptase
  P361:
    value: Q83138685
    source count: 1
    confidence: 0.2
    value label: Telomerase ribonucleoprotein complex - RNA-binding domain, protein family
  P361:
    value: Q83133902
    source count: 1
    confidence: 0.2
    value label: Reverse transcriptase domain, protein family
  P486:
    value: C509186
    source count: 0
    confidence: 0.0
  P527:
    value: Q24769271
    source count: 1
    confidence: 0.2
    value label: Telomerase ribonucleoprotein complex - RNA-binding domain
  P527:
    value: Q24722808
    source count: 1
    confidence: 0.2
    value label: Reverse transcriptase domain
  P637:
    value: NP_001180305
    source count: 1
    confidence: 0.2
  P637:
    value: NP_937983
    source count: 1
    confidence: 0.2
  P638:
    value: 2BCK
    source count: 1
    confidence: 0.2
  P638:
    value: 4B18
    source count: 1
    confidence: 0.2
  P638:
    value: 4MNQ
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14633858
    source count: 3
    confidence: 0.6
    value label: DNA binding
  P680:
    value: Q14865136
    source count: 2
    confidence: 0.4
    value label: nucleotidyltransferase activity
  P680:
    value: Q15315116
    source count: 1
    confidence: 0.2
    value label: telomeric DNA binding
  P680:
    value: Q21101326
    source count: 1
    confidence: 0.2
    value label: tRNA binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q14817968
    source count: 2
    confidence: 0.4
    value label: PML body

value: Q15315102
source count: 1
confidence: 0.2
value label: nuclear telomere cap complex

value: Q21170413
source count: 1
confidence: 0.2
value label: RNA-directed RNA polymerase complex

value: Q14817956
source count: 3
confidence: 0.6
value label: nucleoplasm

value: Q22302888
source count: 1
confidence: 0.2
value label: positive regulation of protein localization to nucleolus

value: Q15315123
source count: 9
confidence: 1.0
value label: telomere maintenance via telomerase

value: Q21101125
source count: 2
confidence: 0.4
value label: DNA biosynthetic process

value: Q14863403
source count: 3
confidence: 0.6
value label: regulation of protein stability

value: Q14818090
source count: 1
confidence: 0.2
value label: replicative senescence

value: Q15315135
source count: 1
confidence: 0.2
value label: TERT

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000309572
source count: 1
confidence: 0.2

value: ENSP00000334346
source count: 1
confidence: 0.2

value: ENSP00000425003
source count: 1
confidence: 0.2

value: ENSP00000499759
source count: 1
confidence: 0.2

value: C0754515
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria
stated in qid: Q24338425
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
stated in qid: Q24336971
retrieved: 2018-01-01

source: hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
stated in qid: Q24310670
retrieved: 2018-07-16

source: An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
stated in qid: Q24336971
retrieved: 2019-04-08

source: Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
stated in qid: Q24313131
retrieved: 2018-07-16

source: Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
stated in qid: Q24291155
retrieved: 2018-07-16

source: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
stated in qid: Q24313396
retrieved: 2018-07-16

source: Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
stated in qid: Q24337394
retrieved: 2018-07-16

source: Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
stated in qid: Q28117179
retrieved: 2018-07-16

source: The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly
stated in qid: Q24301283
retrieved: 2019-04-08

source: Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR
stated in qid: Q24304902
retrieved: 2019-04-08

source: The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme
stated in qid: Q35620887
retrieved: 2019-04-08

source: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
stated in qid: Q24323178
retrieved: 2019-04-08

source: Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
stated in qid: Q24320933
retrieved: 2019-04-08

source: Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
stated in qid: Q24313436
retrieved: 2019-04-08

source: Involvement of telomerase reverse transcriptase in heterochromatin maintenance
stated in qid: Q24337650
retrieved: 2019-04-08

source: HPV E6 protein interacts physically and functionally with the cellular telomerase complex
stated in qid: Q37413480
retrieved: 2019-04-08

source: TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
stated in qid: Q24293589
retrieved: 2019-04-08

source: Telomerase modulates Wnt signalling by association with target gene chromatin
stated in qid: Q24310084
retrieved: 2019-04-08

source: PML-IV functions as a negative regulator of telomerase by interacting with TERT
stated in qid: Q24309336
retrieved: 2019-04-08

source: Functional conservation of the telomerase protein Est1p in humans
stated in qid: Q24299999
retrieved: 2019-04-08

source: The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
stated in qid: Q28118567
retrieved: 2019-04-08

source: Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
stated in qid: Q28117179
retrieved: 2019-04-08

source: Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
stated in qid: Q28115535
retrieved: 2019-04-08

source: Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
stated in qid: Q24320113
retrieved: 2019-04-08

source: Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation
stated in qid: Q24310189
retrieved: 2019-04-08

source: Human Ku70/80 associates physically with telomerase through interaction with hTERT
stated in qid: Q28115815
retrieved: 2019-04-08

source: The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
stated in qid: Q28975759
retrieved: 2019-04-08

wikidata id: Q7697809
domain: protein
level: standard
html url: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809
markdown url: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809.md
facts url summary: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809/facts.json
facts url standard: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809/facts.json
facts url full: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-22T22:38:03.293735Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:22:11.031041+00:00Z