# Telomerase reverse transcriptase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7697809](https://www.wikidata.org/wiki/Q7697809)  
**Source**: https://4ort.xyz/entity/telomerase-reverse-transcriptase-q7697809


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O14746)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
5. [Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
7. [An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
8. [hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
9. [An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
10. [Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
11. [Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
12. [Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
13. [Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
14. [Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
15. [The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
16. [Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
17. [The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
18. [A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
19. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
20. [Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
21. [Involvement of telomerase reverse transcriptase in heterochromatin maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
22. [HPV E6 protein interacts physically and functionally with the cellular telomerase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
23. [TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
24. [Telomerase modulates Wnt signalling by association with target gene chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
25. [PML-IV functions as a negative regulator of telomerase by interacting with TERT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
26. [Functional conservation of the telomerase protein Est1p in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
27. [The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
28. [Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
29. [Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
30. [Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
31. [Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
32. [Human Ku70/80 associates physically with telomerase through interaction with hTERT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
33. [The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
34. [GNL3L stabilizes the TRF1 complex and promotes mitotic transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
35. [Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
36. [Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
37. [Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
38. [Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
39. [Human telomerase contains two cooperating telomerase RNA molecules](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14746&geneProductId=UniProtKB:O14746)
40. [Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
41. [HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
42. [Structure of active dimeric human telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
43. [Cryo-EM structure of substrate-bound human telomerase holoenzyme.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
44. [Differential regulation of telomerase activity by six telomerase subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
45. [Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
46. [Reconstitution of human telomerase activity in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
47. [Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
48. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
49. [Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)
50. [Human telomerase contains two cooperating telomerase RNA molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14746)