# TAR DNA binding protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21133247](https://www.wikidata.org/wiki/Q21133247)  
**Source**: https://4ort.xyz/entity/tar-dna-binding-protein-q21133247


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13148)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
5. [Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
6. [TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
8. [Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
9. [Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
10. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
11. [Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
12. [Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
13. [Molecular mechanism of oxidation‐induced TDP‐43 RRM1 aggregation and loss of function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
14. [Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
15. [ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
16. [TDP‐35 sequesters TDP‐43 into cytoplasmic inclusions through binding with RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
17. [An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
18. [Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
19. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
20. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
21. [Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
22. [Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13148&geneProductId=UniProtKB:Q13148)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
25. [Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
26. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
27. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
28. [TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
29. [TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
30. [USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148)
31. Ensembl Release 99