# Tankyrase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115373](https://www.wikidata.org/wiki/Q21115373)  
**Source**: https://4ort.xyz/entity/tankyrase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O95271)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
5. [Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
6. [Zinc binding catalytic domain of human tankyrase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
7. [NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
8. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
9. [POT1 as a terminal transducer of TRF1 telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
10. [Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
11. [Tankyrase, a poly(ADP-ribose) polymerase at human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
12. [RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
13. [Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
14. [Tankyrase 1 regulates centrosome function by controlling CPAP stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
15. [Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
16. [Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
18. [Tankyrase-1 assembly to large protein complexes blocks its telomeric function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
19. [Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
20. [The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
21. [Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
22. [The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
23. [TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
25. [Tankyrase, a poly(ADP-ribose) polymerase at human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
26. [NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
27. [Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
28. [RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
29. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
30. [Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
31. [The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
32. [Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
34. [Family-wide analysis of poly(ADP-ribose) polymerase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
35. [TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
36. [TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
37. [Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
38. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
39. [Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
40. [Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271)
41. [TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
42. [Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
43. [MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
44. [Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
45. [Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
46. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271)
47. Ensembl Release 99
48. Transporter Classification database