# Tankyrase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111137](https://www.wikidata.org/wiki/Q21111137)  
**Source**: https://4ort.xyz/entity/tankyrase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9H2K2)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
5. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
6. [RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
7. [Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
8. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
9. [Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
10. [Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
11. [Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
12. [Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
13. [Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
14. [The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
16. [RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
17. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
18. [Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
19. [Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
21. [Family-wide analysis of poly(ADP-ribose) polymerase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
22. [Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
23. [TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
24. [Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
25. [Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
26. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2)
27. [Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
28. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2)
29. Ensembl Release 99