# TANK-binding kinase 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988598](https://www.wikidata.org/wiki/Q21988598)  
**Source**: https://4ort.xyz/entity/tank-binding-kinase-1-q21988598


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9WUN2)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
5. [NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
6. [The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
7. [Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
8. [The DEAD‐box helicase DDX3X is a critical component of the TANK‐binding kinase 1‐dependent innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
9. [NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
10. [The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
11. [Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
12. [Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
13. [Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
14. [Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
15. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2)
17. [Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2)
18. [Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2)
19. [Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2)
20. [Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
22. [LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
23. [Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
24. [Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation ofaquaporin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
25. [Immune Activation of Type I IFNs by Listeria monocytogenes Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
26. [Critical Role of AZI2 in GM-CSF–Induced Dendritic Cell Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
27. [Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
28. [Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
29. [The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2)
30. ensembl Release 106