# TANK binding kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111280](https://www.wikidata.org/wiki/Q21111280)  
**Source**: https://4ort.xyz/entity/tank-binding-kinase-1-q21111280


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UHD2)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
6. [Emerging roles for the non-canonical IKKs in cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2)
8. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2)
9. [Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2)
10. [Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
11. [WDFY1 mediates TLR3/4 signaling by recruiting TRIF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
12. [NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
13. [Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
14. [The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
15. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
16. [The Tyrosine Kinase c-Src Enhances RIG-I (Retinoic Acid-inducible Gene I)-elicited Antiviral Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
17. [ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
18. [The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
19. [SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
20. [IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
21. [Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
22. [Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses†](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
23. [RIOK3 Is an Adaptor Protein Required for IRF3-Mediated Antiviral Type I Interferon Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
24. [ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
25. [Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
26. [MAVS Protein Is Attenuated by Rotavirus Nonstructural Protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
27. [The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
28. [A physical and functional map of the human TNF-α/NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
29. [The TBK1-binding domain of optineurin promotes type I interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
30. [Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
31. [STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
32. [A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
33. [Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
34. [Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
35. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
36. [Expanding the substantial interactome of NEMO using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
37. [Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
38. [SINTBAD, a novel component of innate antiviral immunity, shares a TBK1‐binding domain with NAP1 and TANK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
39. [Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-induced Innate Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
40. [Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
41. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
42. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
43. [Activation of STAT6 by STING is critical for antiviral innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
44. [Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
45. [Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
46. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
47. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
48. [Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKKε and TBK-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
49. [Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)
50. [NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2)