# T cell acute lymphocytic leukemia 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14914630](https://www.wikidata.org/wiki/Q14914630)  
**Source**: https://4ort.xyz/entity/t-cell-acute-lymphocytic-leukemia-1


## References

1. UniProt
2. Q20641742
3. [Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
4. [Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
6. [The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
7. [A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
8. [Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
9. [SCL and associated proteins distinguish active from repressive GATA transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
10. [Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
11. [Target-dependent Effect of Phosphorylation on the DNA Binding Activity of the TAL1/SCL Oncoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
12. [RFP represses transcriptional activation by bHLH transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
13. [More than blood, a Novel Gene Required for Mammalian Postimplantation Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
14. [LMO4 Controls the Balance between Excitatory and Inhibitory Spinal V2 Interneurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
15. [Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
16. [Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
17. [ETO2 coordinates cellular proliferation and differentiation during erythropoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
18. [LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
19. [Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
20. [LMO4 Controls the Balance between Excitatory and Inhibitory Spinal V2 Interneurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
21. [The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
22. [Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
24. [Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
25. [The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
26. [The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
28. [The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
29. [SCL and associated proteins distinguish active from repressive GATA transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
30. [LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
31. [The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S 12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
32. [Stem cell leukemia protein directs hematopoietic stem cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
33. [Combinatorial effects ofFlk1andTal1on vascular and hematopoietic development in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
34. [Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
35. [The essential haematopoietic transcription factor Scl is also critical for neuronal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
36. [Scl regulates the quiescence and the long-term competence of hematopoietic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
37. [Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
38. [The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow Monocyte Precursors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
39. [Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)–dependent window during hematopoietic stem-cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
40. [SCL is required for normal function of short-term repopulating hematopoietic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
41. [Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
42. [Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
43. [Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
44. [Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
45. [Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
46. [Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
47. [Selective rescue of early haematopoietic progenitors in Scl –/– mice by expressing Scl under the control of a stem cell enhancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091)
48. [The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
49. [The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)
50. [SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091)