# T-box 5

> mammalian protein found in Mus musculus

**Wikidata**: [Q21980213](https://www.wikidata.org/wiki/Q21980213)  
**Source**: https://4ort.xyz/entity/t-box-5


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70326)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
5. [Differential expression and function of Tbx5 and Tbx20 in cardiac development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
6. [Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
7. [A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
8. [Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
9. [Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
10. [Tbx5-Hedgehog Molecular Networks Are Essential in the Second Heart Field for Atrial Septation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
11. [UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
12. [UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
13. [Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
14. [The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
15. [Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
16. [The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
17. [Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
18. [Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
19. [Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
20. [Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
21. [Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
22. [Reptilian heart development and the molecular basis of cardiac chamber evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
23. [A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
24. [T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
25. [Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
26. [Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70326&geneProductId=UniProtKB:P70326)
28. [Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
29. [Tbx5 is required for forelimb bud formation and continued outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
30. [Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70326)
31. ensembl Release 106