# T-box 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21980210](https://www.wikidata.org/wiki/Q21980210)  
**Source**: https://4ort.xyz/entity/t-box-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70323)
3. Q20641742
4. [Isolation and Characterization of a Gene from the DiGeorge Chromosomal Region Homologous to the MouseTbx1Gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
6. [Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
7. [Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
8. [Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
9. [Ash2l interacts with Tbx1 and is required during early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
10. [Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
11. [Interaction between Tbx1 and HoxD10 and connection with TGFβ-BMP signal pathway during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
12. [Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
13. [The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
14. [The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
15. [Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
16. [Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
17. [Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
18. [Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
19. [Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
20. [Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
21. [Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
22. [TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
23. [Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
24. [In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
25. [Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
26. [In vivo response to high-resolution variation of Tbx1 mRNA dosage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
27. [Suppression of neural fate and control of inner ear morphogenesis by Tbx1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
28. [Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
29. [Tbx1 regulates proliferation and differentiation of multipotent heart progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
30. [Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
31. [The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
32. [Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
33. [Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
34. [Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
35. [Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
36. [A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
37. [Absence of the vagus nerve in the stomach of Tbx1−/− mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
38. [Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
39. [Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
40. [Tbx1 regulates Vegfr3 and is required for lymphatic vessel development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
41. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70323&geneProductId=UniProtKB:P70323)
42. [Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
43. [DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
44. [Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
45. [Early thyroid development requires a Tbx1-Fgf8 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
46. [Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
47. [Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
48. [TBX1 is required for inner ear morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
49. [Mesodermal Tbx1 is required for patterning the proximal mandible in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)
50. [Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70323)