# Synuclein alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q288591](https://www.wikidata.org/wiki/Q288591)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Alpha-synuclein)  
**Source**: https://4ort.xyz/entity/synuclein-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P37840)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
6. [Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
8. [Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
9. [Interactions between fatty acids and alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
10. [Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
11. [Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
12. [Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
13. [Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
14. [Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
15. [Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
16. [Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
17. [Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
18. [Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
19. [Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
20. [Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
21. [α-Synuclein modifies huntingtin aggregation in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
22. [Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
23. [Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
24. [Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
25. [Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
26. [Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
27. [c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
28. [Stimulatory effect of α‐synuclein on the tau‐phosphorylation by GSK‐3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
29. [Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
30. [LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
31. [p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
32. [A role for alpha-synuclein in the regulation of dopamine biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
33. [Regulated interactions of the norepineprhine transporter by the actin and microtubule cytoskeletons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
34. [Molecular motors implicated in the axonal transport of tau and alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
35. [alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
36. [Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262 and Destabilize Microtubule Cytoskeleton in Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
37. [Coordination Features and Affinity of the Cu2+ Site in the α-Synuclein Protein of Parkinson’s Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
38. [Tubulin Seeds α-Synuclein Fibril Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
39. [Evidence that alpha-synuclein does not inhibit phospholipase D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
40. [Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
41. [Dequalinium-induced protofibril formation of alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
42. [α‐Synuclein as an intrinsically disordered monomer – fact or artefact?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
43. [The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
44. [Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
45. [Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
46. [Acceleration of alpha-synuclein aggregation by homologous peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
47. [Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
48. [Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
49. [α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)
50. [Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840)