# Synuclein, alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q14862284](https://www.wikidata.org/wiki/Q14862284)  
**Source**: https://4ort.xyz/entity/synuclein-alpha-q14862284


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O55042)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
5. [Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
6. [Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
7. [Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
8. [α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
9. [Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042)
11. [Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
12. [Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
13. [Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
14. [Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
15. [Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
16. [α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
17. [Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
18. [Ankyrin repeat and BTB/POZ domain containing protein‐2 inhibits the aggregation of alpha‐synuclein: Implications for Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
19. [VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
20. [Synucleins Have Multiple Effects on Presynaptic Architecture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
21. [Role of alpha-synuclein in synaptic glutamate release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
22. [Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
23. [Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
24. [Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
25. [Synaptic vesicle trafficking and Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
26. [Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
27. [alpha-Synuclein produces a long-lasting increase in neurotransmitter release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
28. [Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262 and Destabilize Microtubule Cytoskeleton in Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
29. [Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
30. [Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042)
31. [Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
32. [Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
33. [αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
34. [Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
35. [Alpha-synuclein expression modulates microglial activation phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
36. [Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
37. [Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
38. [Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
39. [Mice lacking alpha-synuclein are resistant to mitochondrial toxins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
40. [Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
41. [Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
42. [Synucleins regulate the kinetics of synaptic vesicle endocytosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55042)
43. [α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O55042&geneProductId=UniProtKB:O55042)
44. ensembl Release 106