# Synthesis of cytochrome C oxidase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21135428](https://www.wikidata.org/wiki/Q21135428)  
**Source**: https://4ort.xyz/entity/synthesis-of-cytochrome-c-oxidase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43819)
3. Q20641742
4. [The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
5. [Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
6. [Cooperation between COA6 and SCO2 in COX2 Maturation during Cytochrome c Oxidase Assembly Links Two Mitochondrial Cardiomyopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
7. [Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
8. [COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
9. [Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
11. [Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
12. [Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
13. [Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
15. [Mutations in SCO2 are associated with autosomal-dominant high-grade myopia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43819)
16. Ensembl Release 99