# Synoviolin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7395294](https://www.wikidata.org/wiki/Q7395294)  
**Source**: https://4ort.xyz/entity/synoviolin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q86TM6)
3. Q20641742
4. [A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
5. [A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
6. [Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
7. [Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
9. [The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
10. [Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
11. [Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
12. [OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
13. [A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
14. [USP14 inhibits ER-associated degradation via interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
15. [Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
16. [Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
17. [IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
18. [A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
19. [Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
20. [Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
21. [HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
23. [Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
24. [CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
25. [Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
26. [Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
27. [A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
29. [Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
30. [Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
31. [HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
32. [Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
33. [Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
34. [CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
35. [SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
36. [SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
37. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
38. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
39. [Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
40. [STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
41. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
42. [STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6)
43. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
44. [Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6)
45. Ensembl Release 99
46. Transporter Classification database