# Synaptotagmin 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560469](https://www.wikidata.org/wiki/Q28560469)  
**Source**: https://4ort.xyz/entity/synaptotagmin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21707)
3. Q20641742
4. [Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
5. [Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
6. [Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
7. [Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
8. [Cis- and trans-membrane interactions of synaptotagmin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
9. [Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
11. [Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
13. [Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
14. [Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
15. [Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
16. [Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
17. [Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
18. [Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
19. [Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
20. [The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
21. [Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
22. [JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
23. [Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
24. [The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
25. [Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
26. [Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
27. [Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
28. [Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
29. [The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
30. [A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
31. [A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
32. [Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
33. [Functional and biochemical analysis of the C2 domains of synaptotagmin IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
34. [Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
35. [Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
36. [Molecular anatomy of a trafficking organelle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
37. [RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
38. [Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
39. [Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
40. [Synaptotagmin IX Regulates Ca2+-dependent Secretion in PC12 Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
41. [Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
42. [LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
43. [Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
44. [A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
45. [Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
46. [The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
47. [Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
48. [Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21707)
49. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21707&geneProductId=UniProtKB:P21707)
50. ensembl Release 106