# Synaptonemal complex protein 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q21990670](https://www.wikidata.org/wiki/Q21990670)  
**Source**: https://4ort.xyz/entity/synaptonemal-complex-protein-3-q21990670


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70281)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
5. [Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
6. [Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
7. [Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
8. [The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
9. [AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
10. [Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
11. [Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
12. [Meiotic failure in male mice lacking an X-linked factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
13. [DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
14. [SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
15. [Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
16. [Meiotic arrest and aneuploidy in MLH3-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
17. [MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
18. [Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
19. [Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
20. [Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
21. [Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
22. [Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
23. [Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
24. [Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
25. [TOPAZ1, a germ cell specific factor, is essential for male meiotic progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
26. [Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
27. [SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
28. [Mili, a mammalian member of piwi family gene, is essential for spermatogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
29. [Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
30. [The mouse polyubiquitin gene Ubb is essential for meiotic progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
31. [Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
32. [The DNA methyltransferase DNMT3C protects male germ cells from transposon activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
33. [Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
34. [Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
35. [Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
36. [FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70281&geneProductId=UniProtKB:P70281)
37. [Meioc maintains an extended meiotic prophase I in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
38. [The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
39. [The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
40. [Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
41. [Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
42. [Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
43. [Meiotic cohesin complexes are essential for the formation of the axial element in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
44. [Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
45. [Meikin is a conserved regulator of meiosis-I-specific kinetochore function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
46. [Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
47. [Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
48. [Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
49. [Sequential assembly of centromeric proteins in male mouse meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)
50. [Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70281)