# SUZ12 polycomb repressive complex 2 subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115982](https://www.wikidata.org/wiki/Q21115982)  
**Source**: https://4ort.xyz/entity/suz12-polycomb-repressive-complex-2-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15022)
3. Q20641742
4. [Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
5. [Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
7. [Nucleosome-interacting proteins regulated by DNA and histone methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
8. [Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
9. [Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
10. [Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
11. [RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
12. [Role of the polycomb repressive complex 2 in acute promyelocytic leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
13. [Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
14. [CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
15. [N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
16. [Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
18. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
19. [Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
20. [The histone variant macroH2A is an epigenetic regulator of key developmental genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
21. [Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
22. [JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
23. [Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
24. [Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
27. [Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
28. [JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
29. [Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
30. [An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
31. [Proteomic characterization of the human sperm nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15022&geneProductId=UniProtKB:Q15022)
32. [Proteomic characterization of the human sperm nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
33. [An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
34. [SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022)
35. Ensembl Release 99