# Survival of motor neuron 2, centromeric

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111707](https://www.wikidata.org/wiki/Q21111707)  
**Source**: https://4ort.xyz/entity/survival-of-motor-neuron-2-centromeric


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3301572)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16637)
4. Q20641742
5. [Gemin8 is required for the architecture and function of the survival motor neuron complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
6. [Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
7. [Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
8. [Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
9. [Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
10. [Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
11. [SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
12. [Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
13. [In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
14. [Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
15. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
16. [A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
17. [Dynamic protein-protein interaction wiring of the human spliceosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
18. [WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
19. [An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
20. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
22. [Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
23. [An orthogonal proteomic survey uncovers novel Zika virus host factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
24. [The SMN interactome includes Myb-binding protein 1a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
25. [Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
26. [Stabilization of the survival motor neuron protein by ASK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
27. [Coilin interacts with Ku proteins and inhibits in vitro non‐homologous DNA end joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
28. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
30. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
31. [A novel nuclear structure containing the survival of motor neurons protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
32. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
33. [The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
34. [A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
35. [Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
36. [Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
37. [The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637)
38. Ensembl Release 99
39. UMLS 2023