# Suppressor of cytokine signaling 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21991681](https://www.wikidata.org/wiki/Q21991681)  
**Source**: https://4ort.xyz/entity/suppressor-of-cytokine-signaling-1-q21991681


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O35716)
3. Q20641742
4. [A new protein containing an SH2 domain that inhibits JAK kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
5. [Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716)
7. [TRIM8/GERP RING finger protein interacts with SOCS-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
8. [Pim serine/threonine kinases regulate the stability of Socs-1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
9. [Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
12. [Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
13. [The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
14. [Structure and function of a new STAT-induced STAT inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
15. [JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
16. [Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716)
17. [Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
18. [Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
19. [SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
20. [Structure and function of a new STAT-induced STAT inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35716&geneProductId=UniProtKB:O35716)
21. [The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35716)
22. ensembl Release 106