# superoxide dismutase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2041084](https://www.wikidata.org/wiki/Q2041084)  
**Source**: https://4ort.xyz/entity/superoxide-dismutase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00441)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
7. [SIRT5 desuccinylates and activates SOD1 to eliminate ROS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
8. [Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
9. [Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
10. [DJ-1 is a copper chaperone acting on SOD1 activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
11. [Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
12. [Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
13. [Development and characterization of human and mouse specific antibodies to CuZn-superoxide dismutase (SOD1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
14. [The Copper Chaperone CCS Directly Interacts with Copper/Zinc Superoxide Dismutase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
15. [Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
16. [Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
17. [Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
18. [BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
19. [Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
20. [A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
21. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
22. [Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
23. [Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
24. [Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
25. [Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
26. [Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
27. [Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
28. [Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
29. [Initiation and elongation in fibrillation of ALS-linked superoxide dismutase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
30. [Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
31. [Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
33. [Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
35. [Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
36. [Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
37. [SIRT5 desuccinylates and activates SOD1 to eliminate ROS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
38. [DJ-1 is a copper chaperone acting on SOD1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
39. [Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
40. [Mutation of SOD1 in ALS: a gain of a loss of function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
41. [Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
42. [Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
43. [Superoxide dismutase isoenzymes in the normal and diseased human cornea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
44. [Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
45. [Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
46. [A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00441)
47. [Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
48. [Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
49. [Mutation of SOD1 in ALS: a gain of a loss of function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)
50. [Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00441&geneProductId=UniProtKB:P00441)