# Sulfatase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21135734](https://www.wikidata.org/wiki/Q21135734)  
**Source**: https://4ort.xyz/entity/sulfatase-1-q21135734


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8IWU6)
3. Q20641742
4. [Functional consequences of the subdomain organization of the sulfs](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
6. [Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
7. [Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
9. [Functional consequences of the subdomain organization of the sulfs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
10. [Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
12. [Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
13. [Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
14. [Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
15. [Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
16. [Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
17. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
18. [HSulf-1 inhibits angiogenesis and tumorigenesis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
19. [Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
20. [HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
21. [Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU6&geneProductId=UniProtKB:Q8IWU6)
22. [Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
23. [Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU6)
24. Ensembl Release 99