# SUFU negative regulator of hedgehog signaling

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173255](https://www.wikidata.org/wiki/Q21173255)  
**Source**: https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UMX1)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
5. [Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
6. [Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
8. [Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
9. [Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
10. [Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
11. [Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
12. [SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
13. [The crosstalk of mTOR/S6K1 and Hedgehog pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
14. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
15. [Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
16. [Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
17. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
18. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
19. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
20. [Gli regulation by the opposing activities of fused and suppressor of fused](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
21. [Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
23. [Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
24. [Gli regulation by the opposing activities of fused and suppressor of fused](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
25. [The sonic hedgehog-patched-gli pathway in human development and disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMX1&geneProductId=UniProtKB:Q9UMX1)
26. [The sonic hedgehog-patched-gli pathway in human development and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMX1)
27. Ensembl Release 99