# SUFU negative regulator of hedgehog signaling

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495920](https://www.wikidata.org/wiki/Q21495920)  
**Source**: https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling-q21495920


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z0P7)
3. Q20641742
4. [Suppressor of fused negatively regulates beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
5. [The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
6. [GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
7. [The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
8. [Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
9. [Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
10. [The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
11. [The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
14. [Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
16. [Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
17. [The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
18. [Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
19. [Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
20. [Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
21. [Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
22. [Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
23. [Global genetic analysis in mice unveils central role for cilia in congenital heart disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
24. [Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
25. [Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
26. [Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
27. [Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7)
28. [Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
29. [SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
30. [Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7)
31. ensembl Release 106