# Stromal interaction molecule 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2356710](https://www.wikidata.org/wiki/Q2356710)  
**Source**: https://4ort.xyz/entity/stromal-interaction-molecule-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13586)
3. Q20641742
4. [STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
6. [Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
7. [Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
8. [An EB1-binding motif acts as a microtubule tip localization signal](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
9. [A protease-independent function for SPPL3 in NFAT activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
10. [TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
11. [A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
12. [Mitochondria control store-operated Ca2+ entry through Na+ and redox signals](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
13. [Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
14. [STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
15. [Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
16. [Junctate is a Ca 2 + -sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
17. [SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
18. [Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
19. [Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
20. [Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
21. [STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
22. [Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
23. [Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
24. [Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
25. [Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
26. [Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
27. [Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
28. [STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
29. [Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
31. [STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
32. [STIM1 and SLC24A4 Are Critical for Enamel Maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
33. [Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
34. [MicroRNA‐185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13586&geneProductId=UniProtKB:Q13586)
35. Ensembl Release 99
36. Transporter Classification database