# SRY-box transcription factor 9

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21127264](https://www.wikidata.org/wiki/Q21127264)  
**Source**: https://4ort.xyz/entity/sry-box-transcription-factor-9-q21127264


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48436)
3. Q20641742
4. [Sex reversal by loss of the C-terminal transactivation domain of human SOX9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
6. [Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
8. [Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
9. [The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
10. [SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
11. [The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
12. [SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
13. [Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
14. [Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
15. [Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
16. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
18. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
19. [Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
20. [Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
22. [Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
23. [RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
24. [Sex reversal by loss of the C-terminal transactivation domain of human SOX9](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
25. [Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
26. [Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
27. [RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
28. [Valve Endothelial Cell–Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
29. [SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
30. [An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
31. [Generation of transgenic mice for conditional overexpression of Sox9](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
32. [Electroporation-Mediated Transfer ofSOX TrioGenes (SOX-5, SOX-6, andSOX-9) to Enhance the Chondrogenesis of Mesenchymal Stem Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
33. [Generation of transgenic mice for conditional overexpression of Sox9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
34. [Electroporation-Mediated Transfer ofSOX TrioGenes (SOX-5, SOX-6, andSOX-9) to Enhance the Chondrogenesis of Mesenchymal Stem Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
35. [Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
36. [Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
37. [Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
38. [Inhibitory role of Notch1 in calcific aortic valve disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48436&geneProductId=UniProtKB:P48436)
39. [The microRNA-29 family in cartilage homeostasis and osteoarthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
40. [Inhibitory role of Notch1 in calcific aortic valve disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
41. [The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48436)
42. Ensembl Release 99
43. UMLS 2023