# SRY-box transcription factor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114866](https://www.wikidata.org/wiki/Q21114866)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SOX2)  
**Source**: https://4ort.xyz/entity/sry-box-transcription-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48431)
3. Q20641742
4. [The cDNA sequence and chromosomal location of the human SOX2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
6. [SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
7. [Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
8. [Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
9. [Core transcriptional regulatory circuitry in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
10. [Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
11. [Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
12. [Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
14. [The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
15. [Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
16. [The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
17. [The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
18. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
19. [Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
20. [Deterministic direct reprogramming of somatic cells to pluripotency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
21. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
25. [Evidence for the presence of stem cell-like progenitor cells in human adult pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
26. [The cDNA sequence and chromosomal location of the human SOX2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
27. [Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
28. [Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
29. [SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
30. [Core transcriptional regulatory circuitry in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
31. [Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
32. [Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
33. [MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
34. [Pluripotency factors regulate definitive endoderm specification through eomesodermin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
35. [SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
36. [Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
37. [Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
38. [Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431)
39. [Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
40. [Pluripotency factors regulate definitive endoderm specification through eomesodermin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431)
41. Ensembl Release 99
42. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)