# SRC proto-oncogene, non-receptor tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109354](https://www.wikidata.org/wiki/Q21109354)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Proto-oncogene_tyrosine-protein_kinase_Src)  
**Source**: https://4ort.xyz/entity/src-proto-oncogene-non-receptor-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL217092)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL49120)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12931)
6. Q20641742
7. [Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
8. [Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931)
11. [A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
12. [Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931)
13. [TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
14. [Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931)
15. [PKCdelta-dependent functional switch of rpS3 between translation and DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
16. [Heme controls the regulation of protein tyrosine kinases Jak2 and Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
17. [Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
18. [EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
19. [Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
20. [Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
21. [Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
22. [Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
23. [The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
24. [LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
25. [PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
26. [Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
27. [Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
28. [The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
29. [Tau interacts with src-family non-receptor tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
30. [Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
31. [Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
32. [The PDZ protein MPP2 interacts with c-Src in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
33. [c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
34. [Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
35. [Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
36. [NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
37. [VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
38. [c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
39. [Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
40. [Functional interaction between c-Src and its mitotic target, Sam 68](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
41. [Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
42. [Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
43. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
44. [Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
45. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
46. [Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
47. [The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
48. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
49. [An inherent role of microtubule network in the action of nuclear receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)
50. [The neurotransmitter dopamine modulates vascular permeability in the endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931)