SPO11 initiator of meiotic double stranded breaks
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Winged helix-like DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: SPO11
additional property: PropertyValue
  property ID: P361
  value: Spo11/DNA topoisomerase VI subunit A superfamily
additional property: PropertyValue
  property ID: P527
  value: Spo11/DNA topoisomerase VI, subunit A, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Meiosis-specific protein Spo11 domain
additional property: PropertyValue
  property ID: P527
  value: Topoisomerase 6 subunit A/Spo11, TOPRIM domain
additional property: PropertyValue
  property ID: P637
  value: NP_001077428
additional property: PropertyValue
  property ID: P637
  value: NP_001077429
additional property: PropertyValue
  property ID: P637
  value: NP_001292363
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: catalytic activity
additional property: PropertyValue
  property ID: P680
  value: hydrolase activity
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: chromosome
additional property: PropertyValue
  property ID: P681
  value: telomere
additional property: PropertyValue
  property ID: P682
  value: protein localization to chromosome
additional property: PropertyValue
  property ID: P682
  value: reciprocal meiotic recombination
additional property: PropertyValue
  property ID: P682
  value: meiotic telomere clustering
additional property: PropertyValue
  property ID: P702
  value: Spo11
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000059056
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000104753
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000104754
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 20
      unique citations norm: 0.008
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 20
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9WTK8
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797502
    source count: 1
    confidence: 0.2
    value label: Winged helix-like DNA-binding domain superfamily
  P361:
    value: Q18037548
    source count: 1
    confidence: 0.2
    value label: SPO11
  P361:
    value: Q41797212
    source count: 1
    confidence: 0.2
    value label: Spo11/DNA topoisomerase VI subunit A superfamily
  P361:
    value: Q83138170
    source count: 1
    confidence: 0.2
    value label: Spo11/DNA topoisomerase VI, subunit A, N-terminal domain, protein family
  P361:
    value: Q83167416
    source count: 1
    confidence: 0.2
    value label: Topoisomerase 6 subunit A/Spo11, TOPRIM domain, protein family
  P527:
    value: Q24745157
    source count: 1
    confidence: 0.2
    value label: Spo11/DNA topoisomerase VI, subunit A, N-terminal
  P527:
    value: Q24783123
    source count: 1
    confidence: 0.2
    value label: Meiosis-specific protein Spo11 domain
  P527:
    value: Q28544169
    source count: 1
    confidence: 0.2
    value label: Topoisomerase 6 subunit A/Spo11, TOPRIM domain
  P637:
    value: NP_001077428
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001077429
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001292363
    source count: 1
    confidence: 0.2
  P637:
    value: NP_036176
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006499680
    source count: 1
    confidence: 0.2
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q1735592
    source count: 1
    confidence: 0.2
    value label: catalytic activity
  P680:
    value: Q14353168
    source count: 1
    confidence: 0.2
    value label: hydrolase activity
  P680:
    value: Q14817981
    source count: 1
    confidence: 0.2
    value label: ATP binding
  P680:
    value: Q14901489
    source count: 1
    confidence: 0.2
    value label: endodeoxyribonuclease activity, producing 5'-phosphomonoesters
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q37748
    source count: 1
    confidence: 0.2
    value label: chromosome

value: Q14872779
source count: 1
confidence: 0.2
value label: telomere

value: Q40260
source count: 1
confidence: 0.2
value label: nucleus

value: Q14762594
source count: 1
confidence: 0.2
value label: nuclear chromosome

value: Q22290904
source count: 1
confidence: 0.2
value label: protein localization to chromosome

value: Q14872801
source count: 2
confidence: 0.4
value label: reciprocal meiotic recombination

value: Q21127387
source count: 1
confidence: 0.2
value label: meiotic telomere clustering

value: Q14864729
source count: 2
confidence: 0.4
value label: male meiosis I

value: Q14877613
source count: 1
confidence: 0.2
value label: DNA metabolic process

value: Q18255873
source count: 1
confidence: 0.2
value label: Spo11

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000059056
source count: 1
confidence: 0.2

value: ENSMUSP00000104753
source count: 1
confidence: 0.2

value: ENSMUSP00000104754
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
stated in qid: Q28592802
retrieved: 2018-03-27

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Zscan4 regulates telomere elongation and genomic stability in ES cells
stated in qid: Q28116840
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

source: Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice
stated in qid: Q28586489
retrieved: 2019-05-09

source: Crossover and noncrossover pathways in mouse meiosis
stated in qid: Q28586370
retrieved: 2018-03-27

source: Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages
stated in qid: Q28506028
retrieved: 2019-05-09

source: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis
stated in qid: Q28591450
retrieved: 2019-05-09

source: Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis
stated in qid: Q28504811
retrieved: 2019-05-09

source: HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes
stated in qid: Q28594947
retrieved: 2019-05-09

source: Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes
stated in qid: Q28591031
retrieved: 2019-05-09

source: Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants
stated in qid: Q24557469
retrieved: 2019-05-09

source: Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
stated in qid: Q28771502
retrieved: 2019-05-09

source: Crossover and noncrossover pathways in mouse meiosis
stated in qid: Q28586370
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21988589
domain: protein
level: standard
html url: https://4ort.xyz/entity/spo11-initiator-of-meiotic-double-stranded-breaks-q21988589
markdown url: https://4ort.xyz/entity/spo11-initiator-of-meiotic-double-stranded-breaks-q21988589.md
facts url summary: https://4ort.xyz/entity/spo11-initiator-of-meiotic-double-stranded-breaks-q21988589/facts.json
facts url standard: https://4ort.xyz/entity/spo11-initiator-of-meiotic-double-stranded-breaks-q21988589/facts.json
facts url full: https://4ort.xyz/entity/spo11-initiator-of-meiotic-double-stranded-breaks-q21988589/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-09T10:47:05.788183Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:56.656023+00:00Z