# Spleen tyrosine kinase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14907340](https://www.wikidata.org/wiki/Q14907340)  
**Source**: https://4ort.xyz/entity/spleen-tyrosine-kinase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48025)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
5. [Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
6. [Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
7. [Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
8. [RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
9. [Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
10. [Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
11. [Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
12. [CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
13. [Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
14. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
15. [STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
16. [Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
17. [Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
18. [TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
19. [Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
20. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
21. [Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
22. [Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
23. [Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
25. [Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
26. [Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
27. [Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
28. [TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
29. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
30. [Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
31. [Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
32. [Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
33. [Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
34. [Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
35. [Syk Expression and Novel Function in a Wide Variety of Tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
36. [Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
38. [Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
39. [CD14 controls the LPS-induced endocytosis of Toll-like receptor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
40. [The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
41. [Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
42. [Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
43. [Syk tyrosine kinase required for mouse viability and B-cell development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
44. [The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
45. [Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
46. [The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
47. [Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
48. [Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)
49. [The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48025&geneProductId=UniProtKB:P48025)
50. [Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48025)