# spleen associated tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7660502](https://www.wikidata.org/wiki/Q7660502)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Tyrosine-protein_kinase_SYK)  
**Source**: https://4ort.xyz/entity/spleen-associated-tyrosine-kinase


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3265032)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL475251)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43405)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
7. [A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
8. [Molecular mechanism of the Syk activation switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
9. [Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
10. [Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
11. [The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
12. [Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
13. [A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
14. [Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
15. [FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
16. [A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
17. [ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
18. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
19. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
20. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
21. [Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
22. [CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
23. [SYK is a critical regulator of FLT3 in acute myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
24. [Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
25. [Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
26. [Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
27. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
28. [Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
29. [Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ‐chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
30. [Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
31. [Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
32. [Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
33. [Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
34. [STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
35. [Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
36. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
37. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
38. [Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
40. [Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
41. [Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
42. [Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
43. [Purification and characterization of human Syk produced using a baculovirus expression system](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
44. [Molecular mechanism of the Syk activation switch](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
45. [Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
46. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405)
47. [SPAP2, an Ig family receptor containing both ITIMs and ITAMs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
48. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
49. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)
50. [Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405)