# Spitz Dmel_CG10334

> protein found in Drosophila melanogaster

**Wikidata**: [Q29816356](https://www.wikidata.org/wiki/Q29816356)  
**Source**: https://4ort.xyz/entity/spitz-dmel-cg10334


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q01083)
3. Q20641742
4. [Localized activation of RTK/MAPK pathways during Drosophila development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
5. [Signaling by the Drosophila epidermal growth factor receptor pathway during development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
6. [The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
7. [Structural basis for EGFR ligand sequestration by Argos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
8. [Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
9. [Argos inhibits epidermal growth factor receptor signalling by ligand sequestration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
10. [Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
11. [EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
12. [The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
13. [Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
14. [Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
17. [Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
18. [Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
19. [R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
20. [Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
21. [Rhomboid cleaves Star to regulate the levels of secreted Spitz](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
22. [Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
23. [Cell proliferation, survival, and death in the Drosophila eye](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
24. [Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
25. [Generating patterns from fields of cells. Examples from Drosophila segmentation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
26. [Epidermal growth factor receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
27. [Multiple EGFR ligands participate in guiding migrating border cells.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
28. [Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
29. [Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
30. [Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
31. [Branching morphogenesis of the Drosophila tracheal system.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
32. [Organ formation in Drosophila: specification and morphogenesis of the salivary gland.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
33. [abdominal A specifies one cell type in Drosophila by regulating one principal target gene.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
34. [Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
35. [Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
36. [EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
37. [EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
38. [Allocation and specification of the genital disc precursor cells in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
39. [Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
40. [Interactive nervous system development: control of cell survival in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
41. [Control of compartment size by an EGF ligand from neighboring cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
42. [Patterning the fly eye: the role of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
43. [Cell fate choices in Drosophila tracheal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01083&geneProductId=UniProtKB:Q01083)
44. [Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
45. [Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
46. [Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
47. [Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
48. [The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
49. [brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)
50. [An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01083)