# Sphingosine kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7576799](https://www.wikidata.org/wiki/Q7576799)  
**Source**: https://4ort.xyz/entity/sphingosine-kinase-1-q7576799


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NYA1)
3. Q20641742
4. [Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
6. [The Nucleotide-binding Site of Human Sphingosine Kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
7. [Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
8. [Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
9. [Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
10. [Sphingosine kinase‐1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
11. [Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
12. [FHL2/SLIM3 Decreases Cardiomyocyte Survival by Inhibitory Interaction With Sphingosine Kinase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
13. [Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
14. [Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
15. [A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1)
17. [Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1)
18. [Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1)
19. [The Nucleotide-binding Site of Human Sphingosine Kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1)
20. [Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
21. [Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
22. [Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
23. [Coupling between endocytosis and sphingosine kinase 1 recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
24. [Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
25. [1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
26. [Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
27. [Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
28. [Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
29. [Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
30. [Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
31. [SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1)
32. Ensembl Release 99