# Sphingomyelin phosphodiesterase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q22676913](https://www.wikidata.org/wiki/Q22676913)  
**Source**: https://4ort.xyz/entity/sphingomyelin-phosphodiesterase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17405)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
5. [Molecular basis of acid sphingomyelinase dificiency in a patient with Niemann-Pick disease type A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
7. [Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
8. [Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
9. [Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
10. [Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
11. [Molecular basis of acid sphingomyelinase dificiency in a patient with Niemann-Pick disease type A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
13. [Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
14. [Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
15. [Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
16. [Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
17. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
18. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
19. [Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
20. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
21. [Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
22. [Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405)
23. [Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
24. [Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405)
25. Ensembl Release 99