# Spatzle Dmel_CG6134

> protein found in Drosophila melanogaster

**Wikidata**: [Q29811410](https://www.wikidata.org/wiki/Q29811410)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Spätzle_(protein))  
**Source**: https://4ort.xyz/entity/spatzle-dmel-cg6134


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48607)
3. Q20641742
4. [Toll gets tied in a knot](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
5. [The immune response of Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
6. [Role of Toll-like receptors in pathogen recognition.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
7. [Conservation and Divergence in Molecular Mechanisms of Axis Formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
8. [The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
9. [Toll we meet again....](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
10. [Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
11. [A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
12. [Toll gets tied in a knot](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
14. [Drosophila neurotrophins reveal a common mechanism for nervous system formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
15. [Wnts as morphogens? The view from the wing of Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
16. [Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
18. [Drosophila neurotrophins reveal a common mechanism for nervous system formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
20. [Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
21. [Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
22. [Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
23. [Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
24. [Multimerization and interaction of Toll and Spätzle in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
25. [Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
27. [Drosophila: the genetics of innate immune recognition and response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
28. [The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
29. [The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
30. [Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
31. [Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
32. [Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
33. [Proteolytic processing of the Drosophila Spätzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
34. [Wnts as morphogens? The view from the wing of Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
35. [Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
36. [The antimicrobial host defense of Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
37. [Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
38. [A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
39. [A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
40. [TheTollPathway Is Required in the Epidermis for Muscle Development in theDrosophilaEmbryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)
41. [Dorsal gradient networks in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
42. [The evolution and genetics of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
43. [Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
44. [Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
45. [Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
46. [Fly immunity: great expectations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
47. [The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
48. [RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
49. [A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P48607&geneProductId=UniProtKB:P48607)
50. [Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48607)